Article
Molecular genetic tests as a guide to surgical management of familial adenomatous polyposis.
Lancet (London, England) - 17 Aug 1996
Vasen H F, van der Luijt R B, Slors J F, Buskens E, de Ruiter P, Baeten C G, Schouten W R, Oostvogel H J, Kuijpers J H, Tops C M, Meera Khan P
Abstract excerpt
BACKGROUND: In familial adenomatous polyposis the only curative treatment is colectomy, and the choice of operation lies between restorative proctocolectomy (RPC) and colectomy with ileorectal anastomosis (IRA). The RPC procedure carries a higher morbidity but, unlike IRA, removes the risk of subsequent rectal cancer. Since the course of familial adenomatous polyposis is influenced by the site of mutation in the...
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