Hyperpolarization-activated cyclic nucleotide-gated channel gene: the most possible therapeutic applications in the field of cardiac biological pacemakers.

Abstract excerpt

The implantation of electronic devices has become the preferred treatment for symptomatic bradyarrhythmias. However, there are many shortcomings in electronic pacemakers. More recently, the data has suggested that application of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel gene may hold great promise in development of biological pacemaker. The evidence for the hypotheses included that: (1)...

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