Identification of susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a two stage genome scan of affected sib-pairs.

doi:10.1007/s004390051048

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Article

Identification of susceptibility loci for nonsyndromic cleft lip with or without cleft palate in a two stage genome scan of affected sib-pairs.

Human genetics - 1 Mar 2000

Prescott N J, Lees M M, Winter R M, Malcolm S

Abstract excerpt

Nonsyndromic cleft lip with or without cleft palate (CL/P) is a complex disorder of multigenic origin involving between two and ten loci. Linkage and association studies of CL/P have implicated a number of candidate genes and regions but have often proved difficult to replicate. Here, we report the findings from a two-stage genome-wide scan of 92 affected sib-pairs to identify susceptibility loci to CL/P. An...

Topics

Chromosome Mapping
Cleft Lip
Cleft Palate
Female
Genetic Linkage
Genetic Predisposition to Disease
Genetic Testing
Humans
Lod Score
Male
Microsatellite Repeats
Nuclear Family
Transforming Growth Factor alpha
United Kingdom

Source

Open in PubMed

Identifiers

PMID: 10798365
DOI: 10.1007/s004390051048

Genes

NPL
TGFA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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