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Article

Genomic Structure and Transcriptional Regulation of the Rat, Mouse, and Human Carboxylesterase Genes

1 Jan 2007

Abstract excerpt

The mammalian carboxylesterases (CESs) comprise a multigene family which gene products play important roles in biotransformation of ester- or amide-type prodrugs. Since expression level of CESs may affect the pharmacokinetic behavior of prodrugs in vivo, it is important to understand the transcriptional regulation mechanism of the CES genes. However, little is known about the gene structure and transcriptional...

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PMID: 17364878
DOI: 10.1080/03602530600952164

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