Genetic and Neutralization Properties of Subtype C Human Immunodeficiency Virus Type 1 Molecular <i>env</i> Clones from Acute and Early Heterosexually Acquired Infections in Southern Africa

Abstract excerpt

A standard panel of subtype C human immunodeficiency virus type 1 (HIV-1) Env-pseudotyped viruses was created by cloning, sequencing, and characterizing functional gp160 genes from 18 acute and early heterosexually acquired infections in South Africa and Zambia. In general, the gp120 region of these clones was shorter (most evident in V1 and V4) and less glycosylated compared to newly transmitted subtype B...

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