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Article

Hsp70 and Hsp40 chaperones do not modulate retinal phenotype in SCA7 mice.

The Journal of biological chemistry - 31 Dec 2004

Helmlinger Dominique, Bonnet Jacques, Mandel Jean-Louis, Trottier Yvon, Devys Didier

Abstract excerpt

Nine neurodegenerative diseases, including spinocerebellar ataxia type 7 (SCA7), are caused by the expansion of polyglutamine stretches in the respective disease-causing proteins. A hallmark of these diseases is the aggregation of expanded polyglutamine-containing proteins in nuclear inclusions that also accumulate molecular chaperones and components of the ubiquitin-proteasome system. Manipulation of HSP70 and...

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Identifiers

PMID: 15494410
DOI: 10.1074/jbc.M409062200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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