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Article

Separation of telomerase functions by reverse genetics

26 Sept 2011

Abstract excerpt

The canonical function of the human telomerase protein (hTERT) is to synthesize telomeric DNA, but it has other biological activities, including enhancing cell proliferation, decreasing apoptosis, regulating DNA damage responses, and increasing cellular proliferative lifespan. The mechanistic relationships among these activities are not understood. We previously demonstrated that ectopic hTERT expression in...

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PMID: 21949400
DOI: 10.1073/pnas.1112414108

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