Article
Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model.
Proceedings of the National Academy of Sciences of the United States of America - 20 Mar 2007
Schauwaers Kris, De Gendt Karel, Saunders Philippa T K, Atanassova Nina, Haelens Annemie, Callewaert Leen, Moehren Udo, Swinnen Johannes V, Verhoeven Guido, Verrijdt Guy, Claessens Frank
Abstract excerpt
Androgens influence transcription of their target genes through the activation of the androgen receptor (AR) that subsequently interacts with specific DNA motifs in these genes. These DNA motifs, called androgen response elements (AREs), can be classified in two classes: the classical AREs, which are also recognized by the other steroid hormone receptors; and the AR-selective AREs, which display selectivity for...
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