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Article

Genomic actions of the androgen receptor are required for normal male sexual differentiation in a mouse model.

Journal of molecular endocrinology - 1 Dec 2005

Notini A J, Davey R A, McManus J F, Bate K L, Zajac J D

Abstract excerpt

Androgens mediate their effects in target cells via the androgen receptor (AR), which acts predominantly as a ligand-dependent transcription factor. In addition, androgens induce rapid activation of second messenger signal transduction cascades, and this is thought to occur via non-genomic mechanisms. We have used the Cre/loxP system to generate an AR knockout (ARKO) mouse targeting exon 3, which encodes the...

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Share to Androgen-Insensitivity Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16326839
DOI: 10.1677/jme.1.01884

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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