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Article

Sertoli cell androgen receptor DNA binding domain is essential for the completion of spermatogenesis.

Endocrinology - 1 Oct 2009

Lim Patrick, Robson Mathew, Spaliviero Jenny, McTavish Kirsten J, Jimenez Mark, Zajac Jeffrey D, Handelsman David J, Allan Charles M

Abstract excerpt

We examined the biological importance of Sertoli cell androgen receptor (AR) genomic interaction, using a Cre-loxP approach to selectively disrupt the AR DNA-binding domain (AR-DBD). Sertoli cell (SC)-specific transgenic Abpa or AMH promoters targeted Cre-mediated inframe excision of mouse Ar exon-3, encoding the AR-DBD second zinc-finger (ZF2), generating SC-specific mutant AR(DeltaZF2) lines designated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19574395
DOI: 10.1210/en.2009-0416

Genes

AMH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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