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Article

A Structural and in Vitro Characterization of Asoprisnil: A Selective Progesterone Receptor Modulator

14 Mar 2007

Abstract excerpt

Selective progesterone receptor modulators (SPRMs) have been suggested as therapeutic agents for treatment of gynecological disorders. One such SPRM, asoprisnil, was recently in clinical trials for treatment of uterine fibroids and endometriosis. We present the crystal structures of progesterone receptor (PR) ligand binding domain complexed with asoprisnil and the corepressors nuclear receptor corepressor (NCoR)...

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PMID: 17356170
DOI: 10.1210/me.2006-0524

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