Article
Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali.
PLoS medicine - 1 Mar 2007
Takala Shannon L, Coulibaly Drissa, Thera Mahamadou A, Dicko Alassane, Smith David L, Guindo Ando B, Kone Abdoulaye K, Traore Karim, Ouattara Amed, Djimde Abdoulaye A, Sehdev Paul S, Lyke Kirsten E, Diallo Dapa A, Doumbo Ogobara K, Plowe Christopher V
Abstract excerpt
BACKGROUND: Malaria vaccines based on the 19-kDa region of merozoite surface protein 1 (MSP-1(19)) derived from the 3D7 strain of Plasmodium falciparum are being tested in clinical trials in Africa. Knowledge of the distribution and natural dynamics of vaccine antigen polymorphisms in populations...
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