Article
Genetic dissection of immunity in leprosy.
Current opinion in immunology - 1 Feb 2005
Alcaïs Alexandre, Mira Marcelo, Casanova Jean-Laurent, Schurr Erwin, Abel Laurent
Abstract excerpt
Leprosy is a chronic infectious disease caused by Mycobacterium leprae that affects an estimated 700,000 new individuals each year. A strong contribution of host genetics to susceptibility to leprosy has long been suggested to account for the considerable variability observed between individuals exposed to M. leprae. As there is no relevant animal model for human leprosy, forward genetics is the main strategy...
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