Article
NF-kappaB-independent induction of endothelial cell apoptosis by the vascular disrupting agent DMXAA.
Anticancer research - 1 Jan 2000
Woon See-Tarn, Hung Sandy S C, Wu Derek C F, Schooltink Mary Ann, Sutherland Rachel, Baguley Bruce C, Chen Qi, Chamley Lawrence W, Ching Lai-Ming
Abstract excerpt
BACKGROUND: DMXAA (5,6-dimethylxanthenone-4-acetic acid; AS1404), a vascular disrupting agent currently in clinical trials, induces tumour endothelial cell apoptosis in vivo in mice and in cancer patients. DMXAA activates NF-kappaB in many different cell types. In this study, whether DMXAA-induce...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.