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Article

Structural Insight into concerted inhibition of alpha 2 beta 2-type aspartate kinase from Corynebacterium glutamicum.

Journal of molecular biology - 27 Apr 2007

Yoshida Ayako, Tomita Takeo, Kurihara Takeshi, Fushinobu Shinya, Kuzuyama Tomohisa, Nishiyama Makoto

Abstract excerpt

Aspartate kinase (AK) catalyzes the first step of the biosynthesis of the aspartic acid family amino acids, and is regulated via feedback inhibition by end-products including Thr and Lys. To elucidate the mechanism of this inhibition, we determined the crystal structure of the regulatory subunit of AK from Corynebacterium glutamicum at 1.58 A resolution in the Thr-binding form, the first crystal structure of the...

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Identifiers

PMID: 17350037
DOI: 10.1016/j.jmb.2007.02.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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