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Article

Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.

Molecular cell - 9 Mar 2007

Bhaskara Venugopal, Dupré Aude, Lengsfeld Bettina, Hopkins Ben B, Chan Angela, Lee Ji-Hoon, Zhang Xiaoming, Gautier Jean, Zakian Virginia, Paull Tanya T

Abstract excerpt

Mre11 and Rad50 are the catalytic components of a highly conserved DNA repair complex that functions in many aspects of DNA metabolism involving double-strand breaks. The ATPase domains in Rad50 are related to the ABC transporter family of ATPases, previously shown to share structural similarities with adenylate kinases. Here we demonstrate that Mre11/Rad50 complexes from three organisms catalyze the reversible...

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Identifiers

PMID: 17349953
DOI: 10.1016/j.molcel.2007.01.028
PMCID: PMC3050042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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