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Article

A multiple-tubes approach for accurate genotyping of very small DNA samples by using PCR: statistical considerations.

American journal of human genetics - 1 Feb 1992

Navidi W, Arnheim N, Waterman M S

Abstract excerpt

A multiple-tubes procedure is described for using PCR to determine the genotype of a very small DNA sample. The procedure involves dividing the sample among several tubes, then amplifying and typing the contents of each tube separately. The results are analyzed by a statistical procedure which determines whether a genotype can be conclusively assigned to the DNA sample. Simulation studies show that this procedure...

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PMID: 1734715
PMCID: PMC1682471

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