Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A multiple-tubes approach for accurate genotyping of very small DNA samples by using PCR: statistical considerations.

American journal of human genetics - 1 Feb 1992

Navidi W, Arnheim N, Waterman M S

Abstract excerpt

A multiple-tubes procedure is described for using PCR to determine the genotype of a very small DNA sample. The procedure involves dividing the sample among several tubes, then amplifying and typing the contents of each tube separately. The results are analyzed by a statistical procedure which de...

Topics

DNA
Genotype
Heterozygote
Homozygote
Humans
Polymerase Chain Reaction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1734715
PMCID: PMC1682471

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1734715-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

A multiple-tubes approach for accurate genotyping of very small DNA samples by using PCR: statistical considerations.PMID 1734715Read ↗

Reliable genotyping of samples with very low DNA quantities using PCR.Semantic proximity Read ↗

Evaluation of standard error and confidence interval of estimated multilocus genotype probabilities, and their implications in DNA forensics.Semantic proximity Read ↗

Modeling one complete versus triplicate analyses in low template DNA typing.Semantic proximity Read ↗

Exploring STR signal in the single- and multicopy number regimes: Deductions from an in silico model of the entire DNA laboratory process.Semantic proximity Read ↗

Reducing chimera formation during PCR amplification to ensure accurate genotyping.Semantic proximity Read ↗

Molecular crowding increases the amplification success of multiple displacement amplification and short tandem repeat genotyping.Semantic proximity Read ↗

A factorial experiment for optimizing the PCR conditions in routine genotyping.Semantic proximity Read ↗

Low-template DNA: A single DNA analysis or two replicates?Semantic proximity Read ↗

Obtaining DNA from a geographically dispersed cohort of current and former smokers: use of mail-based mouthwash collection and monetary incentives.Semantic proximity Read ↗

Interpreting DNA mixtures.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.