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Article

Association of CTLA-4 gene polymorphism with oral squamous cell carcinoma.

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Jan 2006

Wong Y-K, Chang K-W, Cheng C-Y, Liu C-J

Abstract excerpt

BACKGROUND: Oral squamous cell carcinoma (OSCC) is a worldwide problem. The main mechanism of tumor immunity is the destruction of tumor cells by cytolytic T lymphocytes. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4; CD152), a negative regulator of T-lymphocyte activation, plays an extremely important role in the immune tolerance and anergy. This study was designed to investigate the role of CTLA-4...

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Identifiers

PMID: 16393254
DOI: 10.1111/j.1600-0714.2005.00377.x

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