Article
ctla-4 gene variations may influence cervical cancer susceptibility.
Gynecologic oncology - 1 Oct 2010
Rahimifar Shahrzad, Erfani Nasrollah, Sarraf Zahra, Ghaderi Abbas
Abstract excerpt
BACKGROUND: CTLA-4 is the key player of the immune tolerance. Particular genotypes of ctla-4 have been reported to be associated with various diseases. OBJECTIVE: We aimed to evaluate the role of four single nucleotide polymorphisms (SNPs) of ctla-4 gene in cervical cancer. METHODS: 55 patients and 110 healthy controls were genotyped for four polymorphic loci, three in promoter region; -1722(T/C), -1661(A/G),...
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