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Article

Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes.

The Journal of cell biology - 1 Feb 1992

Roulier E M, Fyrberg C, Fyrberg E

Abstract excerpt

We have investigated accumulation of alpha-actinin, the principal cross-linker of actin filaments, in four Drosophila fliA mutants. A single gene is variably spliced to generate one nonmuscle and two muscle isoforms whose primary sequence differences are confined to a peptide spanning the actin b...

Topics

Actin Cytoskeleton
Actinin
Amino Acid Sequence
Animals
Base Sequence
Drosophila
Exons
Larva
Microscopy, Electron
Molecular Sequence Data
Muscles
Mutation
Myofibrils

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

RNA Splicing

Sarcomeres

Source

Open in PubMed Open full text

Identifiers

PMID: 1734023
DOI: 10.1083/jcb.116.4.911
PMCID: PMC2289344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1734023-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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