Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles.

The Journal of experimental biology - 1 Jul 1998

Vigoreaux J O, Hernandez C, Moore J, Ayer G, Maughan D

Abstract excerpt

We have developed a reverse-genetic approach to study the function of flightin, a unique protein of the flight muscle myofibril of Drosophila melanogaster. We describe the generation and characterization of Df(3L)fln1, a lethal genetic deficiency in the 76BE region of the third chromosome which deletes several genes, including the gene for flightin. We show that heterozygous flies harboring the Df(3L)fln1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Deletion
Share to Calcium
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Kinetics

Share to Microscopy, Electron

Share to Muscles

Share to Mutation

Source

Identifiers

PMID: 9622575
DOI: 10.1242/jeb.201.13.2033

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic deficiency that spans the flightin gene of Drosophila melanogaster affects the ultrastructure and function of the flight muscles.PMID 9622575Read ↗

COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle.Semantic proximity Read ↗

Effects of tropomyosin deficiency in flight muscle of Drosophila melanogaster.Semantic proximity Read ↗

Mutations that affect flightin expression in Drosophila alter the viscoelastic properties of flight muscle fibers.Semantic proximity Read ↗

Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles.Semantic proximity Read ↗

Alterations in flightin phosphorylation in Drosophila flight muscles are associated with myofibrillar defects engendered by actin and myosin heavy-chain mutant alleles.Semantic proximity Read ↗

Site directed mutagenesis of Drosophila flightin disrupts phosphorylation and impairs flight muscle structure and mechanics.Semantic proximity Read ↗

Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes.Semantic proximity Read ↗

Alterations in flight muscle ultrastructure and function in Drosophila tropomyosin mutants.Semantic proximity Read ↗

Flightless I and LRRFIP work together to regulate lateral growth of the sarcomeres in <i>Drosophila</i>Semantic proximity Read ↗

Flightin is necessary for length determination, structural integrity, and large bending stiffness of insect flight muscle thick filaments.Semantic proximity Read ↗

Transcriptome analysis of IFM-specific actin and myosin nulls in Drosophila melanogaster unravels lesion-specific expression blueprints across muscle mutations.Semantic proximity Read ↗

Mutations in Drosophila myosin rod cause defects in myofibril assembly.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.