Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of lethal Drosophila melanogaster alpha-actinin mutants.

Biochemical genetics - 1 Oct 1998

Fyrberg C, Ketchum A, Ball E, Fyrberg E

Abstract excerpt

We have partially characterized four Drosophila melanogaster alpha-actinin gene mutants, I(1)2Cb1, I(1)2Cb2, I(1)2Cb4, and I(1)2Cb5. We demonstrate that in each case the mutation is caused by a chromosomal rearrangement that precludes normal protein synthesis. In the absence of alpha-actinin, flies complete embryogenesis and develop into flaccid larvae that die within approximately 24 hr. These larvae have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Southern
Share to Chromosome Mapping
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Insect

Share to Genes, Lethal

Share to Mutation

Share to Restriction Mapping

Share to Time Factors

Source

Identifiers

PMID: 9919356
DOI: 10.1023/a:1018789227987

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of lethal Drosophila melanogaster alpha-actinin mutants.PMID 9919356Read ↗

Molecular genetics of Drosophila alpha-actinin: mutant alleles disrupt Z disc integrity and muscle insertions.Semantic proximity Read ↗

Perturbations of Drosophila alpha-actinin cause muscle paralysis, weakness, and atrophy but do not confer obvious nonmuscle phenotypes.Semantic proximity Read ↗

Drosophila non-muscle alpha-actinin is localized in nurse cell actin bundles and ring canals, but is not required for fertility.Semantic proximity Read ↗

Drosophila alpha-actinin in ovarian follicle cells is regulated by EGFR and Dpp signalling and required for cytoskeletal remodelling.Semantic proximity Read ↗

Insights into the Role of a Cardiomyopathy-Causing Genetic Variant in ACTN2Semantic proximity Read ↗

Multiscale characterization of <i>Caenorhabditis elegans</i> mutants to probe functional mechanisms of human actin pathological variantsSemantic proximity Read ↗

Drosophila basement membrane collagen col4a1 mutations cause severe myopathy.Semantic proximity Read ↗

Alpha spectrin is essential for morphogenesis and body wall muscle formation in Caenorhabditis elegans.Semantic proximity Read ↗

The actinin family of actin cross-linking proteins – a genetic perspectiveSemantic proximity Read ↗

Type IV collagen is essential for proper function of integrin-mediated adhesion in <i>Drosophila</i> muscle fibersSemantic proximity Read ↗

<i>Drosophila</i> Metaxin-2 controls beta-barrel protein biogenesis and muscle growth in a stage-dependent fashionSemantic proximity Read ↗

Duplication in the Microtubule-Actin Cross-linking Factor 1 gene causes a novel neuromuscular conditionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.