Article
Association of soluble CD89 levels with disease progression but not susceptibility in IgA nephropathy.
Kidney international - 1 Dec 2010
Vuong Mai T, Hahn-Zoric Mirjana, Lundberg Sigrid, Gunnarsson Iva, van Kooten Cees, Wramner Lars, Seddighzadeh Maria, Fernström Anders, Hanson Lars Å, Do Lieu Thi, Jacobson Stefan H, Padyukov Leonid
Abstract excerpt
The Fc-α receptor (FcαR/CD89) is involved in IgA complex formation and may affect the development of IgA nephropathy (IgAN). In this study, we tested the genetic variations of the CD89 gene in relation to disease susceptibility in IgAN and the expression of soluble CD89 (sCD89) in sera of patients with IgAN and in controls. There was a significant difference between the levels of sCD89-IgA complexes, measured by...
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