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Article

Type I IFN Signaling on Both B and CD4 T Cells Is Required for Protective Antibody Response to Adenovirus

1 Mar 2007

Abstract excerpt

Recombinant adenoviruses have been used as vehicles for gene therapy as well as vaccination against infectious diseases and cancer. Efficient activation of host B cell response to adenoviral vectors that leads to the generation of protective, neutralizing Ab, represents a major barrier for gene therapy, but an attractive feature for vaccine development. What regulate(s) potent B cell response to adenoviral...

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PMID: 17339445
DOI: 10.4049/jimmunol.178.6.3505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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