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Innate immunity to adenovirus: lessons from mice

26 Nov 2019

Abstract excerpt

Adenovirus is a highly evolutionary successful pathogen, as it is widely prevalent across the animal kingdom, infecting hosts ranging from lizards and frogs to dolphins, birds, and humans. Although natural adenovirus infections in humans rarely cause severe pathology, intravenous injection of high doses of adenovirus-based vectors triggers rapid activation of the innate immune system, leading to cytokine storm...

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PMID: 31769012
DOI: 10.1002/1873-3468.13696

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