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Article

Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG.

Journal of bacteriology - 1 May 2007

Parish Tanya, Roberts Gretta, Laval Francoise, Schaeffer Merrill, Daffé Mamadou, Duncan Ken

Abstract excerpt

Mycolic acids are a key component of the mycobacterial cell wall, providing structure and forming a major permeability barrier. In Mycobacterium tuberculosis mycolic acids are synthesized by type I and type II fatty acid synthases. One of the enzymes of the type II system is encoded by fabG1. We demonstrate here that this gene can be deleted from the M. tuberculosis chromosome only when another functional copy is...

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Identifiers

PMID: 17337570
DOI: 10.1128/JB.01740-06
PMCID: PMC1913321

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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