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Article

The Possible Role of Cytokeratin 8 in Cadmium-Induced Adaptation and Carcinogenesis

1 Mar 2007

Abstract excerpt

Chronic exposures to cadmium compounds are carcinogenic. It was hypothesized that the development of resistance to cadmium may drive carcinogenesis. This is achieved by selection of resistant cells in which the apoptotic response is significantly attenuated. The induction of cadmium resistance in rat lung epithelial cells (LEC) was used to explore the mechanisms of cadmium-induced adaptation and carcinogenesis....

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PMID: 17332340
DOI: 10.1158/0008-5472.can-06-3771

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