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Article

Cadmium modulates H-ras expression and caspase-3 apoptotic cell death in breast cancer epithelial MCF-7 cells.

Journal of inorganic biochemistry - 1 Apr 2013

Petanidis Savvas, Hadzopoulou-Cladaras Margarita, Salifoglou Athanasios

Abstract excerpt

Cadmium (Cd) is a well-known metal carcinogen associated with tumor formation and carcinogenesis. It has been shown to induce cancer through various cellular mechanisms involving inhibition of DNA repair, abnormal gene expression, induction of oxidative stress, and triggering apoptosis. It is well-established that the H-ras oncogene is involved in the process of carcinogenesis with direct effects on cellular...

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Identifiers

PMID: 23376331
DOI: 10.1016/j.jinorgbio.2012.12.015

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