Article
False occurrences of functional motifs in protein sequences highlight evolutionary constraints.
BMC bioinformatics - 1 Mar 2007
Via Allegra, Gherardini Pier Federico, Ferraro Enrico, Ausiello Gabriele, Scalia Tomba Gianpaolo, Helmer-Citterich Manuela
Abstract excerpt
BACKGROUND: False occurrences of functional motifs in protein sequences can be considered as random events due solely to the sequence composition of a proteome. Here we use a numerical approach to investigate the random appearance of functional motifs with the aim of addressing biological questions such as: How are organisms protected from undesirable occurrences of motifs otherwise selected for their...
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