Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Protein protein interactions, evolutionary rate, abundance and age.

BMC bioinformatics - 13 Mar 2006

Saeed Ramazan, Deane Charlotte M

Abstract excerpt

BACKGROUND: Does a relationship exist between a protein's evolutionary rate and its number of interactions? This relationship has been put forward many times, based on a biological premise that a highly interacting protein will be more restricted in its sequence changes. However, to date several studies have voiced conflicting views on the presence or absence of such a relationship. RESULTS: Here we perform a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Conserved Sequence
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Interaction Mapping

Share to Proteins

Share to Sequence Alignment

Share to Sequence Analysis, Protein

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 16533385
DOI: 10.1186/1471-2105-7-128
PMCID: PMC1431566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Protein protein interactions, evolutionary rate, abundance and age.PMID 16533385Read ↗

Evolution of proteins and gene expression levels are coupled in Drosophila and are independently associated with mRNA abundance, protein length, and number of protein-protein interactions.Semantic proximity Read ↗

The Missing Expression Level-Evolutionary Rate Anticorrelation in Viruses Does Not Support Protein Function as a Main Constraint on Sequence Evolution.Semantic proximity Read ↗

Life on the edge: a link between gene expression levels and aggregation rates of human proteinsSemantic proximity Read ↗

The origins of the evolutionary signal used to predict protein-protein interactions.Semantic proximity Read ↗

Protein evolution is faster outside the cell.Semantic proximity Read ↗

Expression level, evolutionary rate, and the cost of expression.Semantic proximity Read ↗

Protein evolution within and between species.Semantic proximity Read ↗

Towards Consensus Gene AgesSemantic proximity Read ↗

Evolutionary rate covariation is a reliable predictor of co-functional interactions but not necessarily physical interactions.Semantic proximity Read ↗

An integrated view of protein evolution.Semantic proximity Read ↗

Age-dependent evolution of the yeast protein interaction network suggests a limited role of gene duplication and divergence.Semantic proximity Read ↗

Young proteins experience more variable selection pressures than old proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.