Article
The human immunodeficiency virus (HIV) gag gene product p18 is responsible for enhanced fusogenicity and host range tropism of the highly cytopathic HIV-1-NDK strain.
Journal of virology - 1 Nov 1992
de Mareuil J, Brichacek B, Salaun D, Chermann J C, Hirsch I
Abstract excerpt
Formation of large syncytia and rapid cell killing are characteristics of the Zairian human immunodeficiency virus type 1 isolate HIV-1-NDK, which is highly cytopathic for CD4+ lymphocytes in comparison with the HIV-1-LAV prototype. Chimeric viruses containing different combinations of HIV-1-NDK genetic determinants corresponding to the splice donor, the packaging signal, and the coding sequence of the p18gag...
Topics
- Amino Acid Sequence
- CD4-Positive T-Lymphocytes
- Cell Fusion
- Democratic Republic of the Congo
- Gene Products, gag
- Genes, Viral
- Genetic Variation
- HIV Infections
- HIV-1
- Humans