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Article

The human immunodeficiency virus (HIV) gag gene product p18 is responsible for enhanced fusogenicity and host range tropism of the highly cytopathic HIV-1-NDK strain.

Journal of virology - 1 Nov 1992

de Mareuil J, Brichacek B, Salaun D, Chermann J C, Hirsch I

Abstract excerpt

Formation of large syncytia and rapid cell killing are characteristics of the Zairian human immunodeficiency virus type 1 isolate HIV-1-NDK, which is highly cytopathic for CD4+ lymphocytes in comparison with the HIV-1-LAV prototype. Chimeric viruses containing different combinations of HIV-1-NDK genetic determinants corresponding to the splice donor, the packaging signal, and the coding sequence of the p18gag...

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Identifiers

PMID: 1357191
DOI: 10.1128/JVI.66.11.6797-6801.1992
PMCID: PMC240181

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