The env gene variability is not directly related to the high cytopathogenicity of an HIV1 variant.

doi:10.1016/0042-6822(90)90543-z

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Article

The env gene variability is not directly related to the high cytopathogenicity of an HIV1 variant.

Virology - 1 Aug 1990

Spire B, Hirsch I, Neuveut C, Sire J, Chermann J C

Abstract excerpt

HIV1-NDK is a Zairian HIV1 isolate which is unique because of its high cytopathic effect on T lymphoblastoid cell lines. Its sequence analysis has indicated 30% divergence with HIV1-LAV/BRU HTLVIII B prototype in the env gene encoding for the envelope glycoprotein gp120. In order to correlate the...

Topics

Animals
CD4 Antigens
Cell Line
Genes, Viral
Genetic Variation
HIV-1
Phenotype
Recombination, Genetic
Restriction Mapping
Transfection
Viral Envelope Proteins
Viral Structural Proteins
Virulence

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