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Article

Mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations.

Genes, chromosomes & cancer - 1 Jun 2007

Christiansen Debes H, Desta Frehiwet, Andersen Mette K, Pedersen-Bjergaard Jens

Abstract excerpt

Activating mutations of the PTPN11 gene encoding the SHP2 tyrosine phosphatase is the most common genetic abnormality in juvenile myelomonocytic leukemia and is sporadically observed in myelodysplasia (MDS) and acute myeloid leukemia (AML). An unselected series of 140 patients with therapy-relate...

Read the complete abstract on PubMed

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Share to Intracellular Signaling Peptides and Proteins
Share to Leukemia, Myeloid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Myelodysplastic Syndromes

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

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Share to Translocation, Genetic

Source

Identifiers

PMID: 17330262
DOI: 10.1002/gcc.20426

Genes

PTPN11
RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17330262-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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