Article
Population-based sequencing of the V3 region of env for predicting the coreceptor usage of human immunodeficiency virus type 1 quasispecies.
Journal of clinical microbiology - 1 May 2007
Delobel Pierre, Nugeyre Marie-Thérèse, Cazabat Michelle, Pasquier Christophe, Marchou Bruno, Massip Patrice, Barre-Sinoussi Françoise, Israël Nicole, Izopet Jacques
Abstract excerpt
Genotypic population-based methods could be faster and less expensive than phenotypic recombinant assays for determining human immunodeficiency virus type 1 (HIV-1) coreceptor usage in patient samples, but their clinical use requires good genotype-phenotype correlation and concordance with clonal analyses. We have assessed these requirements by clonal analysis of the V1 to V3 env PCR products of 26 patients...
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