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Article

Molecular determinants of the interaction between coxsackievirus protein 3A and guanine nucleotide exchange factor GBF1.

Journal of virology - 1 May 2007

Wessels Els, Duijsings Daniël, Lanke Kjerstin H W, Melchers Willem J G, Jackson Catherine L, van Kuppeveld Frank J M

Abstract excerpt

The 3A protein of coxsackievirus B3 (CVB3), a small membrane protein that forms homodimers, inhibits endoplasmic reticulum-to-Golgi complex transport. Recently, we described the underlying mechanism by showing that the CVB3 3A protein binds to and inhibits the function of GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factor 1 (Arf1), thereby interfering with Arf1-mediated COP-I recruitment. This...

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Identifiers

PMID: 17329336
DOI: 10.1128/JVI.02680-06
PMCID: PMC1900206

Genes

GBF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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