Article
IL1RN Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin-1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Aug 2018
Arthur Victoria L, Shuldiner Emily, Remmers Elaine F, Hinks Anne, Grom Alexei A, Foell Dirk, Martini Alberto, Gattorno Marco, Özen Seza, Prahalad Sampath, Zeft Andrew S, Bohnsack John F, Ilowite Norman T, Mellins Elizabeth D, Russo Ricardo, Len Claudio, Oliveira Sheila, Yeung Rae S M, Rosenberg Alan M, Wedderburn Lucy R, Anton Jordi, Haas Johannes-Peter, Rösen-Wolff Angela, Minden Kirsten, Szymanski Ann Marie, Thomson Wendy, Kastner Daniel L, Woo Patricia, Ombrello Michael J
Abstract excerpt
OBJECTIVE: To determine whether systemic juvenile idiopathic arthritis (JIA) susceptibility loci that were identified by candidate gene studies demonstrate association with systemic JIA in the largest study population assembled to date. METHODS: Single-nucleotide polymorphisms (SNPs) from 11 previously reported systemic JIA risk loci were examined for association in 9 populations, including 770 patients with...
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