Article
Common genomic variation in LMNA modulates indexes of obesity in Inuit.
The Journal of clinical endocrinology and metabolism - 1 Jun 2001
Hegele R A, Huff M W, Young T K
Abstract excerpt
We discovered that rare mutations in LMNA, which encodes lamins A and C, underlie autosomal dominant Dunnigan-type familial partial lipodystrophy. Because familial partial lipodystrophy is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation in LMNA is associated with obesity-related phenotypes. We subsequently discovered a common single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.