Functions of multiple exonucleases are essential for cell viability, DNA repair and homologous recombination in recD mutants of Escherichia coli.

doi:10.1534/genetics.105.052076

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Article

Functions of multiple exonucleases are essential for cell viability, DNA repair and homologous recombination in recD mutants of Escherichia coli.

Genetics - 1 Apr 2006

Dermić Damir

Abstract excerpt

Heterotrimeric RecBCD enzyme unwinds and resects a DNA duplex containing blunt double-stranded ends and directs loading of the strand-exchange protein RecA onto the unwound 3'-ending strand, thereby initiating the majority of recombination in wild-type Escherichia coli. When the enzyme lacks its RecD subunit, the resulting RecBC enzyme, active in recD mutants, is recombination proficient although it has only...

Topics

Cell Survival
Chromosome Mapping
Chromosomes
DNA
DNA Repair
Escherichia coli
Escherichia coli Proteins
Exodeoxyribonuclease V
Exonucleases
Genes, Bacterial
Genotype
Models, Genetic
Mutation
Recombination, Genetic
Ultraviolet Rays

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Identifiers

PMID: 16452142
DOI: 10.1534/genetics.105.052076
PMCID: PMC1456380

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