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Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

20 Apr 2020

Abstract excerpt

Bryostatin 1 is a marine natural product under investigation for HIV/AIDS eradication, the treatment of neurological disorders, and enhanced CAR T/NK cell immunotherapy. Despite its promising activity, bryostatin 1 is neither evolved nor optimized for the treatment of human disease. Here we report the design, synthesis, and biological evaluation of several close-in analogs of bryostatin 1. Using a...

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PMID: 32312992
DOI: 10.1038/s41467-020-15742-7

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