Article
Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity.
The Journal of biological chemistry - 13 Apr 2007
Lu Haihui, Pannicke Ulrich, Schwarz Klaus, Lieber Michael R
Abstract excerpt
An XRCC4-like factor, called XLF or Cernunnos, was recently identified as another important factor in the non-homologous DNA end joining (NHEJ) process. NHEJ is the major pathway for the repair of double-strand DNA breaks. The similarity in the putative secondary structures of XLF and XRCC4 as well as the association of XLF with XRCC4.DNA ligase IV in vivo suggested a role in the final ligation step of NHEJ....
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