Correlation of c-fos/c-jun expression with histiocytic differentiation in Hodgkin's Reed-Sternberg cells. Examination in HDLM-1 subclones with spontaneous differentiation.

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Article

Correlation of c-fos/c-jun expression with histiocytic differentiation in Hodgkin's Reed-Sternberg cells. Examination in HDLM-1 subclones with spontaneous differentiation.

The American journal of pathology - 1 Jan 1992

Hsu S M, Xie S S, el-Okda M O, Hsu P L

Abstract excerpt

The c-fos proto-oncogene, which is the normal homolog of the transforming gene carried by murine osteogenic sarcoma viruses, interacts with the protein product of another proto-oncogene, c-jun, to form a heterodimer that can recognize and bind to a specific sequence of nucleotides in the DNA. The expression of c-fos and c-jun is linked to the proliferation of certain cells and the differentiation of others,...

Topics

Adult
Aged
Base Sequence
Cell Transformation, Neoplastic
DNA, Neoplasm
Fluorescent Antibody Technique
Histiocytes
Hodgkin Disease
Humans
Male
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pleural Effusion

Proto-Oncogene Mas

Proto-Oncogene Proteins c-fos

Proto-Oncogene Proteins c-jun

Reed-Sternberg Cells

Tetradecanoylphorbol Acetate

Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 1731522
PMCID: PMC1886249

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1731522-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Correlation of c-fos/c-jun expression with histiocytic differentiation in Hodgkin's Reed-Sternberg cells. Examination in HDLM-1 subclones with spontaneous differentiation.PMID 1731522Read ↗

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