Article
Initiation of Apoptosis by Actin Cytoskeletal Derangement in Human Airway Epithelial Cells
1 Mar 2001
Abstract excerpt
Changes in epithelial cell shape can lead to cell death and detachment. Actin filaments are cleaved during apoptosis, but whether disruption in the actin cytoskeletal network, as one manifestation of cell shape change, can itself induce apoptosis is not known. We tested this hypothesis in the airway epithelial cell line 1HAEo(-) and in primary airway epithelial cells by preventing actin filament elongation with...
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