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Article

Switching leukemia cell phenotype between life and death.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 2004

Tucker Steven J, Rae Colin, Littlejohn Alison F, Paul Andrew, MacEwan David J

Abstract excerpt

Divergent life or death responses of a cell can be controlled by a single cytokine (tumor necrosis factor alpha, TNF) via the signaling pathways that respond to activation of its two receptors (TNFR1 and TNFR2). Here, we show that the choice of life or death can be controlled by manipulation of TNFR signals. In human erythroleukemia patient myeloid progenitor stem cells (TF-1) as well as chronic myelogenous...

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Identifiers

PMID: 15328418
DOI: 10.1073/pnas.0400949101
PMCID: PMC516498

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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