Article
In vitro assessment of artesunate, artemether and amodiaquine susceptibility and molecular analysis of putative resistance-associated mutations of Plasmodium falciparum from São Tomé and Príncipe.
Tropical medicine & international health : TM & IH - 1 Mar 2007
Ferreira Isabel D, Lopes Dinora, Martinelli Axel, Ferreira Conceição, do Rosário Virgílio E, Cravo Pedro
Abstract excerpt
OBJECTIVE: To evaluate the basal in vitro responses of Plasmodium falciparum isolates collected in The Democratic Republic of São Tomé and Príncipe to artemether (ATH), artesunate (ATN) and amodiaquine (AMQ). METHODS: The prevalence of given single nucleotide polymorphisms in the pfmdr1, pfcrt, pftctp and pfATPase6 genes was assessed by PCR-RFLP or DNA sequencing, and gene copy numbers were estimated by real-time...
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