Article
Plasmodium falciparum from Pará state (Brazil) shows satisfactory in vitro response to artemisinin derivatives and absence of the S769N mutation in the SERCA-type PfATPase6.
Tropical medicine & international health : TM & IH - 1 Feb 2008
Ferreira Isabel D, Martinelli Axel, Rodrigues Louise A, do Carmo Ediclei L, do Rosário Virgílio E, Póvoa Marinete M, Cravo Pedro
Abstract excerpt
OBJECTIVE: To evaluate the in vitro efficacy of artesunate (ATN) and artemether (ATH) against Plasmodium falciparum isolates from the Brazilian Amazon state of Pará and to search for mutations and/or altered copy numbers in the putative resistance-associated pfcrt, pfmdr1 and pfATPase6 genes. METHODS: In vitro efficacy of ATN and ATH was successfully measured in 56 freshly collected P. falciparum isolates, using...
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