Article
Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans.
The Biochemical journal - 15 Jun 2007
Brendza Katherine M, Haakenson William, Cahoon Rebecca E, Hicks Leslie M, Palavalli Lavanya H, Chiapelli Brandi J, McLaird Merry, McCarter James P, Williams D Jeremy, Hresko Michelle C, Jez Joseph M
Abstract excerpt
The development of nematicides targeting parasitic nematodes of animals and plants requires the identification of biochemical targets not found in host organisms. Recent studies suggest that Caenorhabditis elegans synthesizes phosphocholine through the action of PEAMT (S-adenosyl-L-methionine:phosphoethanolamine N-methyltransferases) that convert phosphoethanolamine into phosphocholine. Here, we examine the...
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