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Article

Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.

Journal of the National Cancer Institute - 21 Feb 2007

Lagerstedt Robinson Kristina, Liu Tao, Vandrovcova Jana, Halvarsson Britta, Clendenning Mark, Frebourg Thierry, Papadopoulos Nickolas, Kinzler Kenneth W, Vogelstein Bert, Peltomäki Päivi, Kolodner Richard D, Nilbert Mef, Lindblom Annika

Abstract excerpt

BACKGROUND: Preventive programs for individuals who have high lifetime risks of colorectal cancer may reduce disease morbidity and mortality. Thus, it is important to identify the factors that are associated with hereditary colorectal cancer and to monitor the effects of tailored surveillance. In particular, patients with Lynch syndrome, hereditary nonpolyposis colorectal cancer (HNPCC), have an increased risk to...

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Share to Colorectal Neoplasms, Hereditary Nonpolyposis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mismatch Repair

Share to DNA Repair Enzymes

Share to Microsatellite Instability

Share to Mismatch Repair Endonuclease PMS2

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Source

Identifiers

PMID: 17312306
DOI: 10.1093/jnci/djk051

Genes

MLH1
MSH6
BRAF
MSH2
PMS2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Lynch syndrome (hereditary nonpolyposis colorectal cancer) diagnostics.PMID 17312306Read ↗

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Comprehensive molecular analysis of mismatch repair gene defects in suspected Lynch syndrome (hereditary nonpolyposis colorectal cancer) cases.Semantic proximity Read ↗

Identification of mismatch repair gene mutations in young patients with colorectal cancer and in patients with multiple tumours associated with hereditary non-polyposis colorectal cancerSemantic proximity Read ↗

Immunohistochemistry and microsatellite instability testing for selecting MLH1, MSH2 and MSH6 mutation carriers in hereditary non-polyposis colorectal cancer.Semantic proximity Read ↗

Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing.Semantic proximity Read ↗

Population-Based Molecular Detection of Hereditary Nonpolyposis Colorectal CancerSemantic proximity Read ↗

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Lynch syndrome and Lynch syndrome mimics: The growing complex landscape of hereditary colon cancer.Semantic proximity Read ↗

The genetics of HNPCC: application to diagnosis and screening.Semantic proximity Read ↗

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