Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ovarian development in mice requires the GATA4-FOG2 transcription complex.

Development (Cambridge, England) - 1 Nov 2008

Manuylov Nikolay L, Smagulova Fatima O, Leach Lyndsay, Tevosian Sergei G

Abstract excerpt

We have demonstrated previously that mammalian sexual differentiation requires both the GATA4 and FOG2 transcriptional regulators to assemble the functioning testis. Here we have determined that the sexual development of female mice is profoundly affected by the loss of GATA4-FOG2 interaction. We have also identified the Dkk1 gene, which encodes a secreted inhibitor of canonical beta-catenin signaling, as a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta Catenin
Share to Embryo, Mammalian
Share to GATA4 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Mice, Transgenic

Share to Sex Differentiation

Share to Wnt Proteins

Source

Identifiers

PMID: 18927154
DOI: 10.1242/dev.024653

Genes

GATA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ovarian development in mice requires the GATA4-FOG2 transcription complex.PMID 18927154Read ↗

The transcription factor GATA4 is required for follicular development and normal ovarian function.Semantic proximity Read ↗

GATA4 Deficiency Impairs Ovarian Function in Adult Mice1Semantic proximity Read ↗

Developmental expression and spermatogenic stage specificity of transcription factors GATA-1 and GATA-4 and their cofactors FOG-1 and FOG-2 in the mouse testisSemantic proximity Read ↗

Forkhead transcription factors in ovarian functionSemantic proximity Read ↗

GATA proteins work together with friend of GATA (FOG) and C-terminal binding protein (CTBP) co-regulators to control adipogenesis.Semantic proximity Read ↗

<i>Gata4</i> Is Necessary for Normal Pulmonary Lobar DevelopmentSemantic proximity Read ↗

Fog2 excision in mice leads to premature mammary gland involution and reduced Esr1 gene expression.Semantic proximity Read ↗

Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice.Semantic proximity Read ↗

Transgenic mouse models in the study of reproduction: insights into GATA protein function.Semantic proximity Read ↗

Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation.Semantic proximity Read ↗

Simultaneous Gene Deletion of Gata4 and Gata6 Leads to Early Disruption of Follicular Development and Germ Cell Loss in the Murine Ovary1Semantic proximity Read ↗

Transcriptomic analysis and novel insights into lens fibre cell differentiation regulated by Gata3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.