Article
Epigenetic aberration of the human REELIN gene in psychiatric disorders.
Molecular psychiatry - 1 Jun 2007
Tamura Y, Kunugi H, Ohashi J, Hohjoh H
Abstract excerpt
Epigenetic genome modifications such as DNA methylation appear to be involved in various diseases. Here, we suggest that the levels of DNA methylation at the BssHII methylation-sensitive restriction enzyme sites in the human REELIN (RELN) gene in the forebrain vary among individuals. Interestingly, although a statistically significant correlation between the levels of DNA methylation in RELN and age was detected...
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