Article
The role of RELN in lissencephaly and neuropsychiatric disease.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2007
Chang Bernard S, Duzcan Fusun, Kim Seonhee, Cinbis Mine, Aggarwal Abha, Apse Kira A, Ozdel Osman, Atmaca Munevver, Zencir Sevil, Bagci Huseyin, Walsh Christopher A
Abstract excerpt
Reelin is an extracellular matrix-associated protein important in the regulation of neuronal migration during cerebral cortical development. Point mutations in the RELN gene have been shown to cause an autosomal recessive human brain malformation termed lissencephaly with cerebellar hypoplasia (LCH). Recent work has raised the possibility that reelin may also play a pathogenic role in other neuropsychiatric...
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